The most prominent splicing program differences are observed between definitive endoderm and cardiac mesoderm. By performing RNA-Seq on human embryonic stem cells (hESCs) and derived definitive endoderm, cardiac mesoderm, and ectoderm cell lineages, we detect distinct alternative splicing programs associated with each lineage. 9 Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.Īlternative splicing is critical for development however, its role in the specification of the three embryonic germ layers is poorly understood.8 Department of Molecular Genetics, University of Toronto, ONM5S 1A8, Canada.7 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.6 Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.5 Sinsheimer Labs, RNA Center for Molecular Biology, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. 4 Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.3 Donnelly Centre, University of Toronto, Toronto, ONM5S 3E1, Canada.2 Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.1 Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |